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KMID : 0043320100330030363
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Archives of Pharmacal Research
2010 Volume.33 No. 3 p.363 ~ p.367
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An Anti-influenza Component of the Bark of Alnus japonica
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Kim Young-Ho
Kim Jae-Hong
Ra Jeong-Chan
Kim Jeong-Ah
Tung Nguyen Huu
Kwon Hyuk-Joon
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Abstract
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This study to identify anti-influenza components of the bark of Alnus japonica resulted in the isolation of four lupane-type triterpenes (1-4) and one steroid (5). Their structures were characterized on the basis of physicochemical properties, NMR evidence, and ESI-MS data compared with reported data in the literature. Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control.
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KEYWORD
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Alnus japonica, Betulaceae, Lupane triterpene, Anti-influenza, KBNP-0028
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